It's Prudential Ride London Weekend on Saturday and Sunday 30/31 July.
On Saturday this means that there will be significant road closures in The City and Westminster. Around here it will be difficult to drive to the south, but the north and east will be OK See this map The map shows how you can cross London Bridge, Southwark Bridge and Blackfriars Bridge. You need to scroll down a few pages.
The road closures will be from about 6 AM to 6 PM
On Sunday The route goes from The Tower down Upper and Lower Thames street under the Blackfriars onto Victoria Embankment. The roads will closed from about 04:00 to 11:00